Menli I Giray, also spelled as Mengli I Giray, was a khan of the Crimean Khanate (1466, 1469–1475, 1478–1515) and the sixth son of Haci I Giray.
Menli ascended the throne in 1466 for some months, but was then deposed by his brother Nur Devlet. He was restored to the throne in January 1469, but lost power again in March 1475 as a result of a rebellion of the rival brothers and nobility.
In 1475, he was captured by the Ottomans in Feodosiya and delivered to Constantinople. After being forced to recognize Ottoman suzerainty over the Crimean Khanate, he was returned to the throne of Crimea in 1478. He made a great contribution to the development of Crimean Tatar statehood. He founded the fortress of Özü.
In 1502, Menli defeated the last khan of the Golden Horde and took control over its capital Saray. He proclaimed himself Khagan (Emperor), claiming legitimacy as the successor of the Golden Horde's authority over the Tatar khaganates in the Caspian-Volga region.