James V, king of Scotland (1513–42), son and successor of James IV. His mother, Margaret Tudor, held the regency until her marriage in 1514 to Archibald Douglas, 6th earl of Angus, when she lost it to John Stuart, duke of Albany. The factio...

Catherine Parr was born around 1512. She was Henry VIII’s sixth and final wife. Catherine had already been married to a man called Lord Borough. She was in her teens and he was in his sixties when they married. Lord Borough soon died but C...

Gerardus Mercator, Flemish cartographer. He received a master's degree in 1532 from the University of Louvain (Belgium), where he settled. By 24 he was a skilled engraver, calligrapher, and scientific-instrument maker. He and his colleagues...

For nearly 500 years, Machiavelli's observations on Realpolitik have shocked and appalled the timid and romantic, and for many his name was equivalent to the devil's own. Yet, The Prince was the first attempt to write of the world of politi...

Andreas Vesalius was an anatomist, physician, and author of one of the most influential books on human anatomy, De humani corporis fabrica (On the Fabric of the Human Body). Vesalius is often referred to as the founder of modern human anato...

Cristóbal de Mondragón y Mercado was a Spanish general during the Eighty Years' War. He was a prominent military figure of the sixteenth century, and was colonel of one of the Tercios of Flanders under the Duke of Alva, Luis de Requesens...

Anne of Cleves was Henry VIII’s fourth wife. Anne was from the small north German state of Cleves. Her brother, William, ruled Cleves but realised that his sister's marriage to the king of England would greatly enhance his status. After...

Juan Bautista de Toledo, Spanish architect educated in Italy, in the Italian High Renaissance. As many Italian renaissance architects, he had experience in both architecture and military and civil public works. Perhaps he started his caree...

Francisco Álvarez de Toledo, Count of Oropesa, was Spanish viceroy of Peru from November 26, 1569 to September 23, 1581. Toledo became the fifth viceroy of Peru in 1569. He was appointed viceroy by Philip II after serving as a steward in th...

Johann Weyer (in Dutch Jan/Johan/Johannes Wier, in Latin Ioannes Wierus and Piscinarius), was a Dutch physician, occultist and demonologist, disciple and follower of Heinrich Cornelius Agrippa. He was among the first to publish against the...

The principle of a list of forbidden books was adopted at the Fifth Lateran Council in 1515, then confirmed by the Council of Trent in 1546. The first edition of the Index Librorum Prohibitorum, dated 1557 was published by Pope Paul IV. T...

First published in 1516, Thomas More's Utopia is one of the most important works of European humanism. Through the voice of the mysterious traveler Raphael Hythloday, More describes a pagan, communist city-state governed by reason. Addressi...

The Ottoman–Mamluk War of 1516–1517 was a conflict between the Egyptian Mamluk Sultanate and the Ottoman Empire, which led to the fall of the Mamluk Sultanate and the incorporation of Syria, Egypt and the Arabian Peninsula as provinces of t...

Mary I was the Queen of England and Ireland from July 1553 until her death. She is best known for her aggressive and bloody attempt to reverse the English Reformation, which had begun during the reign of her father, Henry VIII. Her pursuit...

The Ninety-Five Theses (original Latin: Disputatio pro declaratione virtutis indulgentiarum) were written by Martin Luther in 1517 and are widely regarded as the initial catalyst for the Protestant Reformation. The disputation protests agai...